ADULT TETANUS, DIPHTHERIA, AND PERTUSSIS VACCINATION AND INCIDENT DEMENTIA

Abstract Adult vaccinations may reduce risk for dementia. We determined whether tetanus, diphtheria, pertussis (Tdap) vaccination is associated with lower Analysis conducted Veterans Health Affairs (VHA) administrative medical record data and replicated in private sector claims data. Patients were ≥65 years of age free dementia 2 prior to index date. Tdap 2011 or 2012. Follow-up through 2018. Controls had no the duration follow-up. After controlling confounding, patients with, compared without vaccination, a significantly both cohorts (VHA: HR=0.58; 95%CI:0.54 - 0.63 MarketScan: 95%CI:0.48 0.70). Results two different clinical sociodemographic characteristics. Several vaccine types are linked decreased risk, suggesting that these associations due nonspecific effects on inflammation rather than vaccine-induced pathogen-specific protective effects.